Role of miRNA manipulation on methylation states of breast cancer stem cell-related gene: Methylation status and miRNAs on BCSCs

The genetic and epigenetic alteration was commonly related to the progression of breast cancer. Epigenetic which comprises DNA methylation microRNA is involved in controlling gene expression cancer cells. change cellular transformation, tumorigenesis, stemness marker were accomplished by this modification. short, non-coding RNAs, are called microRNAs (miRNAs) considered as a master regulator genes associated with management both physiological pathological status. abnormal miRNAs found be contributed progress many types human tumors disrupting action oncogenic suppressor genes. For meantime, tumor affected This occurs due hypermethylation CpG islands within promoter sites, that disturbs suppressing role current article will talk about relationship its effect on adjustment expression.